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Friday, July 17, 2020 | History

1 edition of Modulation of Protein Stability in Cancer Therapy found in the catalog.

Modulation of Protein Stability in Cancer Therapy

Eric Rubin

Modulation of Protein Stability in Cancer Therapy

by Eric Rubin

  • 298 Want to read
  • 6 Currently reading

Published by Springer-Verlag New York in New York, NY .
Written in English

    Subjects:
  • Medicine,
  • Oncology,
  • Immunology,
  • Human genetics,
  • Biochemistry,
  • Microbiology

  • Edition Notes

    Statementedited by Eric Rubin, Kathleen Sakamoto
    ContributionsSakamoto, Kathleen, SpringerLink (Online service)
    The Physical Object
    Format[electronic resource] /
    ID Numbers
    Open LibraryOL25546469M
    ISBN 109780387691435, 9780387691473

    The modulation of androgen action in prostate cancer by exogenous chemicals, efflux transporter P-glycoprotein and Y-box binding protein Creator: Fedoruk, Matthew Nicholas: Date Issued: Description: Prostate cancer is the most frequently diagnosed malignancy and the second leading cause of cancer deaths in : Matthew Nicholas Fedoruk.   Scientists have made a discovery that could reduce the spread of cancer by hindering a protein that binds cancer cells together and allows them to invade tissues. The groundbreaking study.

    Author Summary Protein-protein interaction networks provide a global picture of cellular function and biological processes. The dysfunction of some interactions causes many diseases, including cancer. Proteins interact through their interfaces. Therefore, studying the interface properties of cancer-related proteins will help explain their role in the interaction networks. Cancer immunotherapy (sometimes called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight the is an application of the fundamental research of cancer immunology and a growing subspeciality of oncology.. Cancer immunotherapy exploits the fact that cancer cells often have tumor antigens.

    Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of. Despite the oligonucleotides enormous sensitivity and low in vivo stability, new (nano)technological solutions are expected to enable RNAi clinical application in cancer therapy. Keywords: Epithelial Mesenchymal Transition (EMT), E-cadherin, Metastization,, PI3K/AKT2/TWIST, RNAi nterference (RNAi).


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Modulation of Protein Stability in Cancer Therapy by Eric Rubin Download PDF EPUB FB2

This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome.

This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome.

Specific diseases resulting from deregulated. This comprehensive monograph on the role of protein modulation in cancer therapeutics focuses on targeting molecules that regulate protein stability in a variety of tumors.

Topics covered include ubiquitin ligases, deubiquitinating enzymes, and the : Springer New York. Ubiquitin E3 ligases are the most prevalent cancer genes besides protein kinases, suggesting a critical role in cancer development and progression. Two major classes of E3 ligases can be.

This comprehensive monograph on the role of protein modulation in cancer therapeutics focuses on targeting molecules that regulate protein stability in a variety of tumors.

Topics covered include ubiquitin ligases, deubiquitinating enzymes, and the proteasome. University of Kansas Medical Center Rainbow Boulevard Kansas City, KS | TDD. Inactivation of the von Hippel–Lindau tumor suppressor protein (pVHL) has been linked to a variety of tumors such as renal cell carcinoma, pheochromocytomas, and cerebellar hemangioblastomas.

The best characterized of its many proposed functions is the ability to downregulate hypoxia-inducible factor-α (HIFα) : William Y. Kim, William G.

Kaelin. Figure 4 PPI stabilizers in cancer treatment and in the modulation of immunosuppression. (a) Paclitaxel is a representative allosteric PPI stabilizer that preserves tubulin formation. (b) FK and rapamycin are potent immunosuppressants acting as direct stabilizers of protein interactions with FKBP PPI, protein–protein by:   Ahern, T.

& Manning, M. (eds) Stability of Protein Pharmaceuticals — Part A: Chemical and Physical Pathways of Protein Degradation Cited by: protein stability By increasing the inherent stability of a protein or by lowering the stability threshold, new evolutionary tra-jectories, which would normally be inaccessible as a result of a mutation’s destabilizing effect, may be permitted.

To date, two major strategies to modulate stability and access these pathways have been by: Cancer prevention and therapy through the modulation of the tumor microenvironment Author links open overlay panel Stephanie C.

Casey a Amedeo Amedei b Katia Aquilano c Asfar S. Azmi d Fabian Benencia e Dipita Bhakta f Alan E. Bilsland g Chandra S.

Boosani h Sophie Chen i Maria Rosa Ciriolo c Sarah Crawford j Hiromasa Fujii k Alexandros G Cited by: Whey protein concentrate (WPC) and glutathione modulation in cancer treatment Article Literature Review in Anticancer research 20(6C) November Author: Gustavo Bounous.

The stability of proteins in aqueous solution is routinely enhanced by cosolvents such as glycerol. Glycerol is known to shift the native protein ensemble to more compact states. Glycerol also inhibits protein aggregation during the refolding of many proteins. However, mechanistic insight into protein stabilization and prevention of protein aggregation by glycerol is still by: Cancer therapy has traditionally been based upon the combination of chemotherapy and radiation.

In recent years, the molecular characterization of cancer through genomic, transcriptome and proteomic technologies has led to the development of ‘targeted therapies’ that specifically hit pathways essential for cancer growth and progression [ 3 Cited by: 5.

Modulation Of Protein Function Base de datos de todas episodio Modulation Of Protein Function Estos datos libro es el mejor ranking. EPUB, libros electrónicos EBOOK, Adobe PDF, versión Moblile, ordenador portátil, teléfono inteligente es compatible con todas las herramientas que ♡ Modulation Of Protein Function visitado hoy en ♡ certificado y suministrado tienen el.

University of Copenhagen The Faculty of Health and Medical Sciences. (, May 3). New research uncovers 'stability protein' for cancer treatment. ScienceDaily. Retrieved May 6. Because DNA damage increases p53 protein levels mainly by up-regulating p53 protein stability (Prives, ; Lakin and Jackson, ), we reasoned that IGF-1R inhibition might regulate p53 accumulation in response to DNA damage by influencing p53 protein stability.

Indeed, treatment of R + MEFs with etoposide increased p53 stability (Fig. 3, A Cited by:   In established cancers, autophagy enables tumor cells to survive increased metabolic demands, a hypoxic microenvironment and cancer therapy. Modulation of autophagy may represent a new paradigm for cancer treatment that is relevant to both conventional cytotoxic drugs and to Cited by: We present a fluorogenic method to visualize misfolding and aggregation of a specific protein-of-interest in live cells using structurally modulated fluorescent protein chromophores.

Combining photophysical analysis, X-ray crystallography, and theoretical calculation, we show that fluorescence is triggered by inhibition of twisted-intramolecular charge transfer of these fluorophores in the Cited by: The application of nanoparticles for cancer therapy requires stability in solutions with high protein and salt concentrations.

Controlling the size of the nanoparticles is important because it will influence optical and electric properties, the pharmacokinetics, biodistribution, and accumulation in the tumor by:. Since the identification of the first RNA demethylase and the establishment of methylated RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has emerged as a widespread phenomenon and a critical regulator of transcript expression.

This new layer of regulation is termed “epitranscriptomics.” The most prevalent RNA methylation, N 6-methyladenosine (m6A), Cited by: Generally, your diet provides adequate protein; however while undergoing surgery and treatment for cancer your protein requirements may increase. It is important to be aware of the food sources of protein and to include these foods at every meal and snack.

Your protein requirement. To come up with a quick estimate of your protein requirement. Macro-autophagy is a complex multistep process that facilitates the degradation of damaged and excess proteins and organelles to generate macromolecular building blocks and fuel metabolic pathways (Dikic and Elazar, ).The autophagy pathway has critical roles in core biological processes such as mitochondrial function, cell death, immune surveillance, protein homeostasis, Author: Christina G.

Towers, Darya Wodetzki, Andrew Thorburn.